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The Sinclair Method UK is a method of reducing alcohol consumption using a pill with an 80% success rate in curbing problem drinking. This decades-old treatment method combines a well-established medication, naltrexone (an opioid-blocking medication), with guided coaching. Research suggests it can help around four out of five people with alcohol dependence dramatically reduce their drinking or quit entirely. It has been described it the press as an Ozempic for drinkers .