Tramadol, sold under the brand name Ultram, among others, is an opioid pain medicine used to treat moderate to moderate pain. Once taken by mouth in an immediate-release formulation, pain relief usually begins within an hour. It is also available by injection. It may be sold in combination with paracetamol (acetaminophen) or as long-acting formulations.

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Common side effects include sleepiness during the day, headache, nausea, and diarrhea. Certain side-effects include memory problems, hallucinations, and violence. Driving the following day is not advised with either higher doses or long-acting formulations. Although flumazenil may reverse the effects of zolpidem, generally supportive treatment is all that is recommended for overdose.