Founded in 2010, The Trianni Mouse is an antibody discovery platform with several distinctive and highly attractive features.   Chief among these is the fact that it expresses a full repertoire of variable domains for human antibody heavy and light chains.  In generating its platform, Trianni employed a unique combination of in silico gene design, DNA synthesis, and targeted genomic mutagenesis to modify all three mouse antibody chain loci (Heavy, Kappa, and Lambda).  The new gene segments now embedded in these loci have a novel proprietary optimized structure involving human coding sequences (of V, D, and J) and mouse regulatory sequences (promoters, enhancers, introns, recombination signal sequences).